3du5

Structure of the catalytic subunit of telomerase, TERT

spinqualitylabelsall models 3du5, resolution 3.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3du5 is a 2 chain structure with sequence from Red flour beetle. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3du6 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A common hallmark of human cancers is the overexpression of telomerase, a ribonucleoprotein complex that is responsible for maintaining the length and integrity of chromosome ends. Telomere length deregulation and telomerase activation is an early, and perhaps necessary, step in cancer cell evolution. Here we present the high-resolution structure of the Tribolium castaneum catalytic subunit of telomerase, TERT. The protein consists of three highly conserved domains, organized into a ring-like structure that shares common features with retroviral reverse transcriptases, viral RNA polymerases and B-family DNA polymerases. Domain organization places motifs implicated in substrate binding and catalysis in the interior of the ring, which can accommodate seven to eight bases of double-stranded nucleic acid. Modelling of an RNA-DNA heteroduplex in the interior of this ring demonstrates a perfect fit between the protein and the nucleic acid substrate, and positions the 3'-end of the DNA primer at the active site of the enzyme, providing evidence for the formation of an active telomerase elongation complex. Structure of the Tribolium castaneum telomerase catalytic subunit TERT.,Gillis AJ, Schuller AP, Skordalakes E Nature. 2008 Oct 2;455(7213):633-7. Epub 2008 Aug 31. PMID:18758444 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Telomerase Telomerase 3D structures

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