Pyrin domain

spinqualitylabelsall models NMR structure of pyrin domain in human NLRP7, 2km6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal. Disease Mutations in the protein are the cause of Familial Mediterranean fever.

3D Structures of Pyrin domain

Updated on 13-October-2020

4im6 – hPYD in NLRP1 – human
4ifp - hPYD in NLRP1/MBP
2naq - hPYD in NLRP3 - NMR
6npy - hPYD in NLRP3 + NEK7 - Cryo EM
4ewi - hPYD in NLRP4
6ncv - hPYD in NLRP6 - Cryo EM
6ndj - hPYD in NLRP6/MBP
2km6 – hPYD in NLRP7 – NMR
6z2g - hPYD in NLRP9
2m5v - hPYD in NLRP10
2l6a - hPYD in NLRP12 - NMR
4xhs - hPYD in NLRP12/MBP
4n1j, 4n1k, 4n1l - hPYD in NLRP14
4o7q - hPYD (mutant) in AIM2
3vd8 - hPYD in AIM2/MBP
2wl1 – hPYD PRYSPRY residues 586-776
1pn5 – hPYD in NALP1 - NMR
3qf2 - hPYD in NALP3
1ucp - hPYD in apoptosis-associated speck-like protein – NMR
2hm2 – hPYD in apoptosis-associated speck-like protein2 – NMR
2dbg – hPYD in myeloid cell nuclear differentiation antigen - NMR
2mpc - hPYD in pyrin - NMR
2do9 – mPYD in NALP10 – mouse – NMR
2yu0 – mPYD in interferon-activable protein 205 - NMR

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Michal Harel, Joel L. Sussman