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| Line 11: |
Line 11: |
| *SMase | | *SMase |
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| | **[[5uvg]] – hSMase catalytic domain – human<br /> |
| **[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> | | **[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> |
| **[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> | | **[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> |
| Line 17: |
Line 18: |
| **[[2uyr]] – BcSMase (mutant)<br /> | | **[[2uyr]] – BcSMase (mutant)<br /> |
| **[[7cne]] – SMase C – ''Streptomyces griseocarneus''<br /> | | **[[7cne]] – SMase C – ''Streptomyces griseocarneus''<br /> |
| **[[5uvg]] – hSMase catalytic domain – human<br />
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| *Acid SMase | | *Acid SMase |
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| | **[[5jg8]], [[5i81]], [[5i8r]] – hSMase <br /> |
| | **[[5i85]] – hSMase + phosphocholine<br /> |
| **[[5fib]] – mSMase – mouse<br /> | | **[[5fib]] – mSMase – mouse<br /> |
| **[[5hqn]] – mSMase catalytic domain<br /> | | **[[5hqn]] – mSMase catalytic domain<br /> |
| **[[5fi9]] – mSMase + inhibitor<br /> | | **[[5fi9]] – mSMase + inhibitor<br /> |
| **[[5fic]] – mSMase + lipid<br /> | | **[[5fic]] – mSMase + lipid<br /> |
| **[[5jg8]], [[5i81]], [[5i8r]] – hSMase <br />
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| **[[5i85]] – hSMase + phosphocholine<br />
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| *Acid SMase-like phosphodiesterase | | *Acid SMase-like phosphodiesterase |
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| | **[[5ebb]] – hSMase 3A<br /> |
| | **[[5ebe]] – hSMase 3A + CMP<br /> |
| **[[5fc1]], [[5fc7]], [[5fca]] – mSMase 3A<br /> | | **[[5fc1]], [[5fc7]], [[5fca]] – mSMase 3A<br /> |
| **[[5fcb]] – mSMase 3A + AMP<br /> | | **[[5fcb]] – mSMase 3A + AMP<br /> |
| **[[5fc6]] – mSMase 3A + AMPCP<br /> | | **[[5fc6]] – mSMase 3A + AMPCP<br /> |
| **[[5fc5]] – mSMase 3A + phosphocholine<br /> | | **[[5fc5]] – mSMase 3A + phosphocholine<br /> |
| **[[5ebb]] – hSMase 3A<br />
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| **[[5ebe]] – hSMase 3A + CMP<br />
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| **[[5kar]] – mSMase 3B<br /> | | **[[5kar]] – mSMase 3B<br /> |
| **[[5kas]] – mSMase 3B + phosphocholine<br /> | | **[[5kas]] – mSMase 3B + phosphocholine<br /> |
| Function
Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide[1]. The SMase is classified into 5 types according to their pH dependence and cation dependence. Acid SMase-like phosphodiesterase is a paralog of acid SMase and thus though related by gene duplication has different functions. Acid SMase-like phosphodiesterase 3A hydrolyzes nucleotides triphosphates and diphosphates while Acid SMase-like phosphodiesterase 3B is a GPI-anchored protein with role in inflammatory processes and kidney disease[2].
Disease
Mutations in acid SMase are found in patients with Niemann-Pick disease[3].
- ↑ Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem Phys Lipids. 1999 Nov;102(1-2):79-96. PMID:11001563
- ↑ Gorelik A, Heinz LX, Illes K, Superti-Furga G, Nagar B. Crystal Structure of the Acid Sphingomyelinase-Like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity. J Biol Chem. 2016 Sep 28. pii: jbc.M116.755801. PMID:27687724 doi:https://dx.doi.org/10.1074/jbc.M116.755801
- ↑ Wasserstein MP, Aron A, Brodie SE, Simonaro C, Desnick RJ, McGovern MM. Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease. J Pediatr. 2006 Oct;149(4):554-9. PMID:17011332 doi:https://dx.doi.org/10.1016/j.jpeds.2006.06.034
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3D structures of sphingomyelinase
Updated on 09-November-2020
{"openlevels":0}
- SMase
- 5uvg – hSMase catalytic domain – human
- 3rlh, 3rlg – SMase D (mutant) – Loxosceles intermedia
- 1xx1, 2f9r – SMase I – Loxosceles laeta
- 1zwx – SMase C – Listeria ivanovii
- 2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
- 2uyr – BcSMase (mutant)
- 7cne – SMase C – Streptomyces griseocarneus
- Acid SMase
- Acid SMase-like phosphodiesterase
- 5ebb – hSMase 3A
- 5ebe – hSMase 3A + CMP
- 5fc1, 5fc7, 5fca – mSMase 3A
- 5fcb – mSMase 3A + AMP
- 5fc6 – mSMase 3A + AMPCP
- 5fc5 – mSMase 3A + phosphocholine
- 5kar – mSMase 3B
- 5kas – mSMase 3B + phosphocholine
- Alkaline SMase
- 5udy – hSMase
- 5tcd – hSMase + phosphocholine
References
