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==Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein==
==Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein==
<StructureSection load='2a26' size='340' side='right' caption='[[2a26]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='2a26' size='340' side='right'caption='[[2a26]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2a26]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A26 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2a26]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A26 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a25|2a25]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a25|2a25]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CACYBP, S100A6BP, SIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CACYBP, S100A6BP, SIP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a26 OCA], [http://pdbe.org/2a26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a26 RCSB], [http://www.ebi.ac.uk/pdbsum/2a26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2a26 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a26 OCA], [https://pdbe.org/2a26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a26 RCSB], [https://www.ebi.ac.uk/pdbsum/2a26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a26 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CYBP_HUMAN CYBP_HUMAN]] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).<ref>PMID:16085652</ref>   
[[https://www.uniprot.org/uniprot/CYBP_HUMAN CYBP_HUMAN]] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).<ref>PMID:16085652</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Ely, K R]]
[[Category: Ely, K R]]
[[Category: Fukushima, T]]
[[Category: Fukushima, T]]

Revision as of 08:24, 27 January 2021

Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein

2a26, resolution 1.20Å

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