1h6i

A REFINED STRUCTURE OF HUMAN AQUAPORIN 1

spinqualitylabelsall models 1h6i, resolution 3.54Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1h6i is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 1fqy, 1hw0, 1ih5 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [AQP1_HUMAN] Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel. A refined structure of human aquaporin-1.,de Groot BL, Engel A, Grubmuller H FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Aquaporin Aquaporin 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA