Plexin

spinqualitylabelsall models Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Plexin (PLX) is the receptor for semaphorin. Plexin A controls axon guidance. Plexin B regulates Rho GTPase. Plexin C is the receptor for GPI-anchored semaphorin Sema7A. Structural highlights Plexin C1 interactions with semaphoric SEMA7A. Water molecules are shown as red spheres. Ca coordination site.

3D structures of plexin

13-January-2022

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• Plexin A
  • 5l56, 5l59, 5l5c – mPLX-A1 extracellular domain segment 1-10 - mouse
    
  • 5l7n – mPLX-A1 extracellular domain segment 7-10
    
  • 3ryt - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate
    
  • 3q3j - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human
    
  • 3al8, 3oky – mPLX-A2 + semaphorin-6A
    
  • 4gza - mPLX-A2 + semaphorin-3A + neuropilin-1
    
  • 3al9 – mPLX-A2 SEMA+PSI domain
    
  • 3okt - mPLX-A2 extracellular domain segment 1-4
    
  • 5l5g – mPLX-A2 extracellular domain segment 1-8
    
  • 5l74 – mPLX-A2 extracellular domain segment 4-5
    
  • 3ig3 - mPLX-A3 intracellular domain
    
  • 4e74 - hPLX-A4 Rho GTPase-binding domain
    
  • 5l5k, 5l5l – mPLX-A4 extracellular domain
    
  • 5l5k – mPLX-A4 extracellular domain segment 1-10
    
  • 5l5l – mPLX-A4 extracellular domain segment 1-8
    
  • 5l5m, 5l5n – mPLX-A4 extracellular domain segment 1-7
    
  • 7m0r – mPLX-A4 + neuropilin + semaphorin - CryoEM
    
  • 6fkm, 6fkn - PLX-A + semaphoring – Drosophila melanogaster
    
• Plexin B
  • 2r2o – hPLX-B1 effector domain
  • 2rex - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
  • 2jph - hPLX-B1 effector domain – NMR
    
  • 3ol2 - hPLX-B1 + semaphorin 4D
  • 3sua, 3su8 – hPLX-B1 + RAS-related C3 botulinum toxin substrate
  • 3hm6 - hPLX-B1 cytoplasmic domain + peptide
    
  • 5b4w - hPLX-B1 residues 20-535 + peptide inhibitor
    
  • 4e71 - hPLX-B2 effector domain
    
  • 5e6p - hPLX-B2 cytoplasmic domain + Rho guanine nucleotide exchange factor 11
    
  • 7kdc – mPLX-B2 receptor binding domain 1463-1565 + RhoD
    
• Plexin C
  • 3kuz - hPLX-C1 ubiquitin-like domain
  • 3nvn, 3nvq – hPLX-C1 + semaphorin 7A
    
  • 6vxk - hPLX-C1 + semaphorin-like protein – Cryo EM
    
  • 4m8n - PLX-C1 intracellular domain + RAP1B – zebra fish
    
• Plexin D
  • 3h6n - hPLX-D1 ubiquitin-like domain
    
  • 5v6r - mPLX-D1 intracellular domain
    
  • 5v6t - mPLX-D1 intracellular domain + GIPC1
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman