3p7o: Difference between revisions
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==Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides== | ==Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides== | ||
<StructureSection load='3p7o' size='340' side='right' caption='[[3p7o]], [[Resolution|resolution]] 2.14Å' scene=''> | <StructureSection load='3p7o' size='340' side='right'caption='[[3p7o]], [[Resolution|resolution]] 2.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3p7o]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3p7o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P7O FirstGlance]. <br> | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ide ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ide ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p7o OCA], [https://pdbe.org/3p7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p7o RCSB], [https://www.ebi.ac.uk/pdbsum/3p7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p7o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/IDE_RAT IDE_RAT]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3p7o" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3p7o" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
[[Category: Insulysin]] | [[Category: Insulysin]] | ||
[[Category: Large Structures]] | |||
[[Category: Noinaj, N]] | [[Category: Noinaj, N]] | ||
[[Category: Rodgers, D W]] | [[Category: Rodgers, D W]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Metallopeptidase]] | [[Category: Metallopeptidase]] | ||
