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==Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)==
==Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)==
<StructureSection load='3q91' size='340' side='right' caption='[[3q91]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3q91' size='340' side='right'caption='[[3q91]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q91 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q91 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q90|3q90]], [[3q93|3q93]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q90|3q90]], [[3q93|3q93]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT14, UGPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT14, UGPP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-sugar_diphosphatase UDP-sugar diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.45 3.6.1.45] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-sugar_diphosphatase UDP-sugar diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.45 3.6.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q91 OCA], [http://pdbe.org/3q91 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q91 RCSB], [http://www.ebi.ac.uk/pdbsum/3q91 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q91 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q91 OCA], [https://pdbe.org/3q91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q91 RCSB], [https://www.ebi.ac.uk/pdbsum/3q91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q91 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN]] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.  
[[https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN]] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.  
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: UDP-sugar diphosphatase]]
[[Category: UDP-sugar diphosphatase]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H]]

Revision as of 05:58, 8 June 2022

Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)

3q91, resolution 2.70Å

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