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==Crystal Structure of the zinc-dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-bound State==
==Crystal Structure of the zinc-dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-bound State==
<StructureSection load='3tgn' size='340' side='right' caption='[[3tgn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3tgn' size='340' side='right'caption='[[3tgn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tgn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGN FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">adcR, SPD_2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=373153 STRP2])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">adcR, SPD_2000 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=373153 STRP2])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgn OCA], [http://pdbe.org/3tgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tgn RCSB], [http://www.ebi.ac.uk/pdbsum/3tgn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgn OCA], [https://pdbe.org/3tgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgn RCSB], [https://www.ebi.ac.uk/pdbsum/3tgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ADCR_STRP2 ADCR_STRP2]] Zinc-responsive regulator that acts both as a repressor and as an activator by regulating directly the promoters of its target genes. In the presence of zinc, directly represses the expression of the adcRCBA operon, of genes coding for a group of surface antigen zinc-binding pneumococcal histidine triad proteins (PhtA, PhtB, PhtD and PhtE), and of adcAII. Can also activate expression of adh.<ref>PMID:20804771</ref> <ref>PMID:21603707</ref>   
[[https://www.uniprot.org/uniprot/ADCR_STRP2 ADCR_STRP2]] Zinc-responsive regulator that acts both as a repressor and as an activator by regulating directly the promoters of its target genes. In the presence of zinc, directly represses the expression of the adcRCBA operon, of genes coding for a group of surface antigen zinc-binding pneumococcal histidine triad proteins (PhtA, PhtB, PhtD and PhtE), and of adcAII. Can also activate expression of adh.<ref>PMID:20804771</ref> <ref>PMID:21603707</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Strp2]]
[[Category: Strp2]]
[[Category: Giedroc, D P]]
[[Category: Giedroc, D P]]
Retrieved from "https://proteopedia.org/3tgn"