4fco: Difference between revisions
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==Crystal structure of bace1 with its inhibitor== | ==Crystal structure of bace1 with its inhibitor== | ||
<StructureSection load='4fco' size='340' side='right' caption='[[4fco]], [[Resolution|resolution]] 1.76Å' scene=''> | <StructureSection load='4fco' size='340' side='right'caption='[[4fco]], [[Resolution|resolution]] 1.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fco]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4fco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCO FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0U4:N-[(2S,3R)-4-{[2-(1-BENZYLPIPERIDIN-4-YL)ETHYL]AMINO}-3-HYDROXY-1-PHENYLBUTAN-2-YL]-5-[METHYL(METHYLSULFONYL)AMINO]-N-[(1R)-1-PHENYLETHYL]BENZENE-1,3-DICARBOXAMIDE'>0U4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0U4:N-[(2S,3R)-4-{[2-(1-BENZYLPIPERIDIN-4-YL)ETHYL]AMINO}-3-HYDROXY-1-PHENYLBUTAN-2-YL]-5-[METHYL(METHYLSULFONYL)AMINO]-N-[(1R)-1-PHENYLETHYL]BENZENE-1,3-DICARBOXAMIDE'>0U4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fco OCA], [https://pdbe.org/4fco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fco RCSB], [https://www.ebi.ac.uk/pdbsum/4fco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fco ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
==See Also== | ==See Also== | ||
*[[Beta secretase|Beta secretase]] | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Chen TT]] | ||
[[Category: Chen | [[Category: Chen WY]] | ||
[[Category: Li | [[Category: Li L]] | ||
[[Category: Xu | [[Category: Xu YC]] | ||
Revision as of 04:48, 7 October 2022
Crystal structure of bace1 with its inhibitor
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