4fsa: Difference between revisions

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<StructureSection load='4fsa' size='340' side='right'caption='[[4fsa]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='4fsa' size='340' side='right'caption='[[4fsa]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fsa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymmo Zymmo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FSA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fsa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FSA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0V3:6-AMINO-2-(METHYLAMINO)-4-[2-({[TRANS-4-(PYRIDIN-3-YLETHYNYL)CYCLOHEXYL]METHYL}AMINO)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0V3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0V3:6-AMINO-2-(METHYLAMINO)-4-[2-({[TRANS-4-(PYRIDIN-3-YLETHYNYL)CYCLOHEXYL]METHYL}AMINO)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0V3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fr6|4fr6]], [[4fr1|4fr1]], [[3eos|3eos]], [[4fps|4fps]], [[3v0y|3v0y]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fsa OCA], [https://pdbe.org/4fsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fsa RCSB], [https://www.ebi.ac.uk/pdbsum/4fsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fsa ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 ZYMMO])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fsa OCA], [http://pdbe.org/4fsa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fsa RCSB], [http://www.ebi.ac.uk/pdbsum/4fsa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fsa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]  
[https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]


==See Also==
==See Also==
*[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]]
*[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Zymmo]]
[[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]]
[[Category: Immekus, F]]
[[Category: Immekus F]]
[[Category: Klebe, G]]
[[Category: Klebe G]]
[[Category: Biosynthesis]]
[[Category: Glycosyltransferase]]
[[Category: Queuosine]]
[[Category: Tim barrel]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Trna]]
[[Category: Trna processing]]

Revision as of 20:08, 19 October 2022

tRNA-Guanine Transglycosylase soaked with pyridyl-alkine-substituted lin-benzoguanine ligand

4fsa, resolution 1.62Å

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