4g83: Difference between revisions

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<StructureSection load='4g83' size='340' side='right'caption='[[4g83]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
<StructureSection load='4g83' size='340' side='right'caption='[[4g83]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4g83]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G83 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4g83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G83 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vd0|3vd0]], [[3vd1|3vd1]], [[3vd2|3vd2]], [[4g82|4g82]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g83 OCA], [https://pdbe.org/4g83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g83 RCSB], [https://www.ebi.ac.uk/pdbsum/4g83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g83 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HUMAN, P73, TP73 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g83 OCA], [http://pdbe.org/4g83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g83 RCSB], [http://www.ebi.ac.uk/pdbsum/4g83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g83 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ethayathulla, A S]]
[[Category: Ethayathulla AS]]
[[Category: Viadiu, H]]
[[Category: Viadiu H]]
[[Category: Beta-immunoglobulin fold]]
[[Category: Dna binding protein-dna complex]]
[[Category: Tumor suppressor]]

Revision as of 20:29, 19 October 2022

Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element

4g83, resolution 4.00Å

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