4ga8: Difference between revisions
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==Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil== | ==Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil== | ||
<StructureSection load='4ga8' size='340' side='right' caption='[[4ga8]], [[Resolution|resolution]] 1.94Å' scene=''> | <StructureSection load='4ga8' size='340' side='right'caption='[[4ga8]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ga8]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ga8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GA8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SBI:SORBINIL'>SBI</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SBI:SORBINIL'>SBI</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ga8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ga8 OCA], [https://pdbe.org/4ga8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ga8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ga8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ga8 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref> | ||
==See Also== | |||
*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cousido-Siah A]] | ||
[[Category: Mitschler | [[Category: Mitschler A]] | ||
[[Category: Podjarny | [[Category: Podjarny A]] | ||
[[Category: | [[Category: Ruiz Figueras FX]] | ||
Revision as of 06:45, 26 October 2022
Human AKR1B10 mutant V301L complexed with NADP+ and sorbinil
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