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==Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae==
==Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae==
<StructureSection load='4koe' size='340' side='right' caption='[[4koe]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
<StructureSection load='4koe' size='340' side='right'caption='[[4koe]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4koe]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KOE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4koe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KOE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TR6:TROVAFLOXACIN'>TR6</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TR6:TROVAFLOXACIN'>TR6</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foe|3foe]], [[3fof|3fof]], [[2nov|2nov]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[4kpe|4kpe]], [[4kpf|4kpf]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4koe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4koe OCA], [https://pdbe.org/4koe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4koe RCSB], [https://www.ebi.ac.uk/pdbsum/4koe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4koe ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parC, SP_0855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN]), parE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4koe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4koe OCA], [http://pdbe.org/4koe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4koe RCSB], [http://www.ebi.ac.uk/pdbsum/4koe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4koe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> 
[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>  
 
==See Also==
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Strpn]]
[[Category: Large Structures]]
[[Category: Fisher, L M]]
[[Category: Streptococcus pneumoniae TIGR4]]
[[Category: Laponogov, I]]
[[Category: Fisher LM]]
[[Category: Pan, X S]]
[[Category: Laponogov I]]
[[Category: Sanderson, M R]]
[[Category: Pan X-S]]
[[Category: Veselkov, D A]]
[[Category: Sanderson MR]]
[[Category: Isomerase-dna-inhibitor complex]]
[[Category: Veselkov DA]]
[[Category: Protein-dna cleavage complex]]
[[Category: Quinolone]]
[[Category: Topoisomerase iia]]
[[Category: Trovafloxacin]]

Revision as of 09:03, 7 December 2022

Quinolone(Trovafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae

4koe, resolution 3.02Å

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