4ldr: Difference between revisions

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==Structure of the S283Y mutant of MRDI==
==Structure of the S283Y mutant of MRDI==
<StructureSection load='4ldr' size='340' side='right' caption='[[4ldr]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='4ldr' size='340' side='right'caption='[[4ldr]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ldr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ldr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDR FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ldq|4ldq]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldr OCA], [https://pdbe.org/4ldr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldr RCSB], [https://www.ebi.ac.uk/pdbsum/4ldr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldr ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MRI1, MRDI, UNQ6390/PRO21135 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5-thioribose-1-phosphate_isomerase S-methyl-5-thioribose-1-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.23 5.3.1.23] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldr OCA], [http://pdbe.org/4ldr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ldr RCSB], [http://www.ebi.ac.uk/pdbsum/4ldr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
[https://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
[[Category: Large Structures]]
[[Category: Metzner, S I]]
[[Category: Metzner SI]]
[[Category: Sousa, M C]]
[[Category: Sousa MC]]
[[Category: Templeton, P D]]
[[Category: Templeton PD]]
[[Category: Cell invasion]]
[[Category: Helix bundle]]
[[Category: Isomerase]]
[[Category: Rossmann-like fold]]
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