4lt5: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA== | ==Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA== | ||
<StructureSection load='4lt5' size='340' side='right' caption='[[4lt5]], [[Resolution|resolution]] 2.89Å' scene=''> | <StructureSection load='4lt5' size='340' side='right'caption='[[4lt5]], [[Resolution|resolution]] 2.89Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lt5]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4lt5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naegleria_gruberi Naegleria gruberi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LT5 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lt5 OCA], [https://pdbe.org/4lt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lt5 RCSB], [https://www.ebi.ac.uk/pdbsum/4lt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lt5 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TET1_NAEGR TET1_NAEGR] Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), and thereby plays a role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).<ref>PMID:24390346</ref> <ref>PMID:26323320</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cheng | [[Category: Naegleria gruberi]] | ||
[[Category: Correa | [[Category: Cheng X]] | ||
[[Category: Dai | [[Category: Correa IR]] | ||
[[Category: Fu | [[Category: Dai N]] | ||
[[Category: Hashimoto | [[Category: Fu ZQ]] | ||
[[Category: Pais | [[Category: Hashimoto H]] | ||
[[Category: Roberts | [[Category: Pais JE]] | ||
[[Category: Saleh | [[Category: Roberts RJ]] | ||
[[Category: Zhang | [[Category: Saleh L]] | ||
[[Category: Zheng | [[Category: Zhang X]] | ||
[[Category: Zheng Y]] | |||
