Sphingomyelinase: Difference between revisions
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== Function == | == Function == | ||
'''Sphingomyelinase''' (SMase) or '''sphingomyelin phosphodiesterase''' is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and [[Ceramide]]<ref>PMID:11001563</ref>. The SMase is classified into 5 types according to their pH dependence and cation dependence. '''Acid SMase-like phosphodiesterase''' is a paralog of '''acid SMase''' and thus though related by gene duplication has different functions. '''Acid SMase-like phosphodiesterase 3A''' hydrolyzes nucleotides triphosphates and diphosphates while '''Acid SMase-like phosphodiesterase 3B''' is a GPI-anchored protein with role in inflammatory processes and kidney disease<ref>PMID:27687724</ref>. | '''Sphingomyelinase''' (SMase) or '''sphingomyelin phosphodiesterase''' is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and [[Ceramide]]<ref>PMID:11001563</ref>. The SMase is classified into 5 types according to their pH dependence and cation dependence. '''Acid SMase-like phosphodiesterase''' is a paralog of '''acid SMase''' and thus though related by gene duplication has different functions. '''Acid SMase-like phosphodiesterase 3A''' hydrolyzes nucleotides triphosphates and diphosphates while '''Acid SMase-like phosphodiesterase 3B''' is a GPI-anchored protein with role in inflammatory processes and kidney disease<ref>PMID:27687724</ref>. | ||
See also [[Lipid signaling]]. | |||
== Disease == | == Disease == | ||
