Alcohol dehydrogenase 3D structures

3D Structures of Alcohol dehydrogenase

Updated on 16-February-2023

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• ADH I
  • 2vna - hADH I catalytic domain - human
    
  • 3jv7 – RrADH I – Rhodococcus rubber
    
  • 4w6z – yADH I – yeast
    
  • 7kcq – yADH I – Cryo EM
    
  • 4eex – LlADH I – Lactococcus lactis
    
  • 4eez – LlADH I (mutant)
• ADH I binary complex
  • 1u3t – hADH I α chain + inhibitor
    
  • 1hsz, 1hdz, 3hud - hADH I β chain + NAD
    
  • 1u3w - hADH I γ chain + inhibitor
    
  • 1ht0 - hADH I γ chain (mutant) + NAD
    
  • 7kc2, 7kjy – yADH I + NAD – Cryo EM
    
  • 6c49 – ADH I + Zn – Acinetobacter baumannii
    
  • 6qhe – ADH + NAD – Arthrobacter
    
• ADH I ternary complex
  • 2w98, 2w4q – hADH I catalytic domain + NADP + inhibitor
    
  • 1hso - hADH I α chain + NAD + pyrazole derivative
    
  • 1hdx - hADH I β chain + NAD + alcohol
    
  • 1u3u, 1u3v - hADH I β chain + inhibitor
    
  • 1deh, 1hdy - hADH I β chain + NAD + pyrazole derivative
    
  • 1htb - hADH I β3 chain + NAD + pyrazole derivative
    
  • 3fx4 – pADH I + NADP + inhibitor – pig
    
  • 4w6z – yADH I + Zn + NAD derivative
    
  • 5env – yADH I + Zn + NAD + alcohol
    
  • 6ffx – RrADH I + Zn + NAD
    
  • 6ffz, 5o8h, 5o8q, 5o9d, 5o9f, 6fg0, 5od3 – RrADH I (mutant) + Zn + NAD
    
• ADH II
  • 3owo – ZmADH II iron-dependent – Zymomonas mobilis
• ADH II complex
  • 3cos - hADH II + NAD + Zn
    
  • 1e3e – mADH II + NADH – mouse
    
  • 1e3l - mADH II (mutant) + NADH
    
  • 1e3i - mADH II + NADH + inhibitor
    
  • 5yln – ADH II + Zn – Streptococcus pneumoniae
    
  • 3ox4 - ZmADH II iron-dependent + NAD
    
• ADH III
  • 1m6h, 1m6w, 1teh - hADH III χ chain
    
  • 2fze - hADH III χ chain + ADP-ribose
    
  • 2fzw, 1mp0 - hADH III χ chain + NAD
    
  • 1mc5 – hADH III χ chain + glutathione + NADH
    
  • 1ma0 - hADH III χ chain + dodecanoic acid + NAD
    
  • 3qj5 - hADH III χ chain + inhibitor + NAD
    
  • 4dl9, 4dlb – tADH III + NAD – tomato
    
  • 4dla – tADH III
    
  • 5mln – ADH III + NADPH – Candida magnoliae
    
  • 5yat – ADH III + Zn – Komagsaataella phaffii
    
• ADH IV
  • 1ye3, 8adh, 5adh, 4xd2 - hoADH IV e chain – horse
    
  • 1qlj - hoADH IV e chain (mutant)
    
  • 3iv7 – ADH IV – Corynebacterium glutamicum
• ADH IV binary complex
  • 1d1s, 1agn – hADH IV σ chain + NAD
    
  • 1d1t - hADH IV σ chain (mutant) + NAD
    
  • 2jhf, 2jhg, 1het, 1heu, 1hf3, 1ee2, 2oxi, 2ohx, 6adh, 7udd - hoADH IV e chain + NAD
    
  • 6nbb - hoADH IV e chain + NAD – Cryo EM
    
  • 1adb, 1adc, 1adf, 1adg, 7adh, 5vn1 - hoADH IV e chain + NAD derivative
    
  • 1mgo, 1ju9, 1qlh, 1a72 - hoADH IV e chain (mutant) + NAD
    
• ADH IV ternary complex
  • 3oq6, 1qv6, 1qv7, 1a71, 1axe, 1axg, 4nfh, 4nfs, 4ng5, 5kje, 5kjc, 5kj6, 5kj1, 5kcz, 5kcp, 5cdt, 5cds, 5cdg, 6o91, 6oa7, 6owm, 6owp – hoADH IV e chain (mutant) + NAD + alcohol
    
  • 4dwv, 4dxh, 5kjf, 6xt2, 7jqa, 7k35, 7ua6, 7uc9, 7uca, 7ucu, 7ude, 7udr, 7uec, 7uee, 7uef, 7uei, 7uej, 7uhv, 7uhw]], 7uhx - hoADH IV e chain + NAD + alcohol
    
  • 1p1r, 1ldy, 1lde - hoADH IV e chain + NADH + formamide derivative
    
  • 1n92 - hoADH IV e chain + NAD + pyrazole derivative
    
  • 1bto, 3bto - hoADH IV e chain + NADH + butylthiolane derivative
    
  • 1n8k - hoADH IV e chain (mutant) + NAD + pyrazole
    
  • 1mg0, 1hld - hoADH IV e chain + NAD + alcohol
    
  • 5vj5 - hoADH IV e chain + Zn + phenanthroline
    
  • 5vjg - hoADH IV e chain + Zn + bipyridine
    
  • 5vkr - hoADH IV e chain + Zn + ADPR
    
  • 5vl0 - hoADH IV e chain + Zn + formamide derivative
    
  • 6cy3, 6cxx - hoADH IV e chain (mutant) + Zn + dephosphoCoA
    
  • 5cdu - hoADH IV e chain (mutant) + Zn + NAD + pyrazole
    
• ADH
  • 1a4u – SlADH – Scaptodrosophila lebanonensis
    
  • 3my7 – ADH ACDH domain – Vibrio parahaemolyticus
    
  • 3meq – ADH – Brucella suis
    
  • 3l4p – ADH – Desulfovibrio gigas
    
  • 1jvb - SsADH – Sulfolobus solfataricus
    
  • 3i4c, 1nto, 1nvg – SsADH (mutant)
    
  • 3goh – ADH – Shewanella oneidensis
    
  • 3gaz – ADH residues 2-334 – Novosphingobium aromaticivorans
    
  • 2eih – ADH – Thermus thermophilus
    
  • 1rjw, 6iqd – GsADH – Geobacillus stearothermophilus
    
  • 1vj0, 1vhd – TmADH -Thermotoga maritima
    
  • 2eer – ADH – Sulfolobus tokodaii
    
  • 3uog – ADH – Sinorhizobium meliloti
    
  • 4bmn – ReADH - Ralstonia eutropha
    
  • 4z6k – ADH - Moraxella
    
  • 7cyi – ADH – Artemisia annua
    
• ADH binary complex
  • 1agn – hADH (sigma) +NAD
    
  • 1cdo – ADH + NAD - cod
    
  • 3l77, 3tn7 – ADH short-chain + NADP – Thermococcus sibiricus
    
  • 1h2b – ADH + NAD – Aeropyrum pernix
    
  • 1f8f – Benzyl-ADH + NAD – Acinetobacter calcoaceticus
    
  • 1o2d - TmADH + NADP
    
  • 3ip1 – TmADH + Cd
    
  • 1b16, 1b14, 1b15 - SlADH + NAD derivative
    
  • 3pii – GsADH + butyramide
    
  • 3rj5, 3rj9 – SlADH (mutant) + NAD
    
  • 3s1l – ReADH + Zn
    
  • 3jzd – ReADH + NAD
    
  • 4rqt - AtADH P + Zn – Arabidopsis thaliana
    
  • 7bu2 – EcADH + Zn – Escherichia coli
    
  • 6qhe – ADH + NAD – Arthrobacter
    
  • 6z42 – ADH + Zn – Halomonas elongata
    
• ADH ternary complex
  • 3cv7 – pADH + NAD + NAP
    
  • 1mg5 – ADH + NADH + acetate – Drosophila melanogaster
    
  • 1r37 – SsADH + NAD + alcohol
    
  • 1sby – SlADH + NAD + alcohol
    
  • 1b2l - SlADH + NAD + cyclohexanone
    
  • 1llu - ADH + NAD + alcohol – Pseudomonas aeruginosa
    
  • 3rf7 – SoADH + NAD + Fe + Ni
    
  • 3s2e – ReADH + NAD + Zn
    
  • 3s2f, 3s2g – ReADH + NAD + Zn + furfural
    
  • 4gkv – EcADH + NAD + Zn + peptide
    
  • 7bu3 – EcADH + NADP + Zn + Asp
    
  • 5vm2 – EcADH + Mg + Zn
    
  • 4jji, 4gl4, 3uko, 4rqu - AtADH III + NAD + Zn
    
  • 4l0q - AtADH III (mutant) + NAD + Zn
    
  • 4cpd – TtADH + NAD + Zn
    
  • 6n7l – ADH + NAD + Zn – Elizabethkingia anophelis
    
  • 6c76 – TthADH + NADP + Fe – Thermococcus thioreducens
    
  • 6c7l – TthADH + monophosphoadenosine diphosphate
    
  • 6c75 – TthADH + NADP + Fe + monophosphoadenosine diphosphate
    
• NADP-dependent ADH
  • 4gac - mADH
    
  • 4hfj – toADH – tobacco
    
  • 2nvb - TbADH (mutant) – Thermoanaerobacter brockii
    
  • 3ftn, 3fpc, 3fpl, 3fsr – ADH chimera
    
  • 1y9a - EhADH – Entamoeba histolytica
    
  • 2oui – EhADH (mutant)
    
  • 1p0c – RpADH8 – Rana perezi
    
• NADP-dependent ADH complex
  • 1ykf – TbADH + NADP
    
  • 3h4g – pADH + NADP
    
  • 1p0f – RpADH + NADP
    
  • 4hfm - toADH + NADP
    
  • 4hfn - toADH + NADP + coniferaldehyde
    
  • 4jbg - PaADH + Zn – Pyrobaculum aerophilum
    
  • 4jbh - PaADH + Zn + Co
    
  • 4jbi - PaADH + NADP + Zn
    
  • 4bms – ReADH + NADPH
    
  • 4bmv – ADH + NADPH – Sphingobium yanoikuyae
    
  • 5o98 – ADH + NADPH – Catharanthus roseus
    
  • 5yvm – bspADH + Mn + NADP derivative – brine sea pool
    
  • 5yvr, 5yvs – bspADH (mutant) + Mn + NADP
    
  • 5z2x, 7c3v – ADH + NADP – Kluyveromyces polyspora
    
• R-specific ADH
  • 1nxq, 6h07, 6h1m - LbRADH – Lactobacillus brevis
    
  • 1zk2, 1zk3, 6hlf, 6y0z, 6y10, 6y15, 6y1b, 6y1c - LbRADH (mutant)
    
  • 1zjy, 1zjz, 1zk0, 1zk1 – LbRADH (mutant) + NADH + alcohol
    
  • 1zk4 - LbRADH (mutant) + NADH + acetophenone
    
  • 4rf4 – LkADH + Mg - Lactobacillus kefiri
    
  • 4rf5, 4rf3 – LkADH (mutant) + Mg
    
  • 4rf2 – LkADH + Mg + NADP
    
• Specific alcohol ADH
  • 2cf5, 2cf6 – Cinnamyl-AtADH
    
  • 1piw, 1q1n, 1ps0 – Cinnamyl-yADH
    
  • 3two - Cinnamyl-ADH + NADP – Helicobacter pylori
    
  • 1m2w – Mannitol-ADH – Pseudomonas fluorescens
    
  • 1w6s – Methanol-ADH – Methylobacterium extorquens
    
  • 1yqx – Sinapyl-aADH II – aspen
    
  • 1yqd – Sinapyl-aADH II + NADP
    
  • 1bdb – Biphenyl dihydrodiol-ADH + NAD - Pseudomonas
• Quinohemoprotein ADH
  • 1kv9, 1yiq – PpQADH II + PQQ + heme – Pseudomonas putida
    
  • 6zcw - PpQADH II + PQQ + Pr
    
  • 1kb0 - QADH I + PQQ + heme – Comamonas testosteroni
• Quinone-dependent ADH
  • 4cvc, 4cvb – ADH + Zn + PQQ + propanoate – Pseudogluconobacter saccharoketogenes
    
• Secondary ADH
  • 7uut, 7ux4 – TpSADH (mutant) + NADP + alcohol
    
  • 6kq9, 6kqb - SADH – Micrococcus luteus
    
  • 1rhc – SADH +F420-acetone – Methanoculleus thermophilus
    
  • 7utc – TeSADH + DMSO + NADP + Zn – Thermoanaerobacter ethanolicus
    
  • 7uut – TeSADH (mutant) + NADP + Zn
    
  • 1ped - CbSADH – Clostridium beijerinckii
    
  • 2b83, 1jqb – CbSADH (mutant)
    
  • 1kev – CbSADH + NADPH
    
  • 1bxz – CbSADH catalytic domain + alcohol
    
  • 2xaa – RrSADH I + NAD + alcohol
    
• Hydroxyacyl-CoA dehydrogenase (HADH)
  • Short chain HADH (SCHAD)
    • 1so8 – hSCHAD II
      
    • 3rqs - hSCHAD
      
    • 1f14 - hSCHAD (mutant)
  • Short chain HADH binary complex
    • 1f12 - hSCHAD (mutant) + hydroxybutyryl-CoA
      
    • 1f17, 1lsj, 1lso - hSCHAD (mutant) + NAD
      
    • 1zbq - hSCHAD IV + NAD
      
    • 1e3s - rSCHAD + NAD – rat
  • Short chain HADH ternary complex
    • 1u7t - hSCHAD II + inhibitor + NAD
      
    • 1f0y - hSCHAD + acetoacetyl-CoA + NAD
      
    • 1il0, 1m75, 1m76 - hSCHAD (mutant) + acetoacetyl-CoA + NAD
      
    • 1e3w - rSCHAD + 3-keto-butyrate + NAD
      
    • 1e6w - rSCHAD + estradiol + NAD
      
• Unspecified HADH
  • 1uay - HADH II – Thermus thermophilus
    
  • 1zej, 3ctv - HADH – Archaeoglobus fulgidus
    
  • 1zcj - rHADH
    
  • 2x58 - rHADH + CoA
    
  • 2et6 – HADH (mutant) – Candida tropicalis

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