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==Crystal Structure of a Functionally Uncharacterized Domain of E3 Ubiquitin Ligase SHPRH==
==Crystal Structure of a Functionally Uncharacterized Domain of E3 Ubiquitin Ligase SHPRH==
<StructureSection load='4qn1' size='340' side='right' caption='[[4qn1]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
<StructureSection load='4qn1' size='340' side='right'caption='[[4qn1]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qn1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QN1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QN1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn1 OCA], [https://pdbe.org/4qn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qn1 RCSB], [https://www.ebi.ac.uk/pdbsum/4qn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn1 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SHPRH, KIAA2023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qn1 OCA], [http://pdbe.org/4qn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qn1 RCSB], [http://www.ebi.ac.uk/pdbsum/4qn1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qn1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN]] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref>
[https://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref>  
 
==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Dong, A]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Dong A]]
[[Category: Guan, X]]
[[Category: Edwards AM]]
[[Category: Li, Y]]
[[Category: Guan X]]
[[Category: Structural genomic]]
[[Category: Li Y]]
[[Category: Tong, Y]]
[[Category: Tong Y]]
[[Category: Walker, J R]]
[[Category: Walker JR]]
[[Category: Zhang, Q]]
[[Category: Zhang Q]]
[[Category: E3 ligase]]
[[Category: Ring]]
[[Category: Sgc]]
[[Category: Shprh]]
[[Category: Ubiquitin]]
[[Category: Unknown function]]

Revision as of 13:41, 22 February 2023

Crystal Structure of a Functionally Uncharacterized Domain of E3 Ubiquitin Ligase SHPRH

4qn1, resolution 2.48Å

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