7x4f: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Native CD-NTase LpCdnE== | |||
<StructureSection load='7x4f' size='340' side='right'caption='[[7x4f]], [[Resolution|resolution]] 2.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7x4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X4F FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x4f OCA], [https://pdbe.org/7x4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x4f RCSB], [https://www.ebi.ac.uk/pdbsum/7x4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x4f ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CDNE2_LEGPN CDNE2_LEGPN] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection (Probable). A type I-B(UU) CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> <ref>PMID:32839535</ref> Cyclic dinucleotide synthase that catalyzes the synthesis of 3',3'-cyclic UMP-UMP (c-di-UMP) as the major product, and of 3',3'-cyclic CMP-UMP as a minor product, that are second messengers for cell signal transduction.<ref>PMID:30787435</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Legionella pneumophila]] | |||
[[Category: Chen Y]] | |||
[[Category: Hou MH]] | |||
[[Category: Ko TP]] | |||
[[Category: Wang YC]] | |||
[[Category: Yang CS]] | |||
