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<StructureSection load='4woz' size='340' side='right'caption='[[4woz]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
<StructureSection load='4woz' size='340' side='right'caption='[[4woz]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4woz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WOZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4woz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WOZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN9:2-(ACETYLAMINO)-2-DEOXY-D-MANNOSE'>MN9</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN9:2-(ACETYLAMINO)-2-DEOXY-D-MANNOSE'>MN9</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nanA, CdNal ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 "Bacillus difficilis" Hall and O'Toole 1935])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4woz OCA], [https://pdbe.org/4woz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4woz RCSB], [https://www.ebi.ac.uk/pdbsum/4woz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4woz ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4woz OCA], [http://pdbe.org/4woz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4woz RCSB], [http://www.ebi.ac.uk/pdbsum/4woz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4woz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/D5Q364_PEPDI D5Q364_PEPDI]] Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.[HAMAP-Rule:MF_01237][SAAS:SAAS00160136]  
[https://www.uniprot.org/uniprot/D5Q364_CLODI D5Q364_CLODI] Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.[HAMAP-Rule:MF_01237]
 
==See Also==
*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus difficilis hall and o'toole 1935]]
[[Category: Clostridioides difficile]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: N-acetylneuraminate lyase]]
[[Category: Chen X]]
[[Category: Chen, X]]
[[Category: Cui YF]]
[[Category: Cui, Y F]]
[[Category: Guo RT]]
[[Category: Guo, R T]]
[[Category: Liu WD]]
[[Category: Liu, W D]]
[[Category: Wu QQ]]
[[Category: Wu, Q Q]]
[[Category: Zhu DM]]
[[Category: Zhu, D M]]
[[Category: Aldolase]]
[[Category: Lyase]]
[[Category: Thermostable]]

Revision as of 07:18, 7 April 2023

Crystal Structures of CdNal from Clostridium difficile in complex with mannosamine

4woz, resolution 1.96Å

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