4zcf: Difference between revisions

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<StructureSection load='4zcf' size='340' side='right'caption='[[4zcf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4zcf' size='340' side='right'caption='[[4zcf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zcf]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZCF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4ZCF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zcf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZCF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ecoP15Imod ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), ecoP15Ires ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zcf OCA], [https://pdbe.org/4zcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zcf RCSB], [https://www.ebi.ac.uk/pdbsum/4zcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zcf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4zcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zcf OCA], [http://pdbe.org/4zcf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zcf RCSB], [http://www.ebi.ac.uk/pdbsum/4zcf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zcf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/T3RE_ECOLX T3RE_ECOLX] A type III restriction enzyme that recognizes 2 inversely oriented double-stranded sequences 5'-CAGCAG-3' and cleaves DNA 25-27 base pairs downstream of one site. DNA restriction requires both the Res and Mod subunits (PubMed:11178902, PubMed:15464603). DNA topology affects its action; relaxed and negatively supercoiled DNA are digested but positively supercoiled DNA is not a good substrate (PubMed:11178902). Interacts with DNA approximately one half-turn downstream of the recognition site (PubMed:26067164). After binding to one recognition site undergoes random one-dimensional diffusion along DNA until it collides with a stationary enzyme bound to the second DNA site, which is when DNA cleavage occurs (Probable).<ref>PMID:11178902</ref> <ref>PMID:15464603</ref> <ref>PMID:26067164</ref> <ref>PMID:26067164</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aggarwal, A K]]
[[Category: Aggarwal AK]]
[[Category: Chan, S H]]
[[Category: Chan SH]]
[[Category: Gupta, Y K]]
[[Category: Gupta YK]]
[[Category: Xu, S Y]]
[[Category: Xu SY]]
[[Category: Asymmetric dna methylation]]
[[Category: Atp motor]]
[[Category: Dna methyltransferase]]
[[Category: Hydrolase-dna complex]]
[[Category: Hydrolase/dna]]
Retrieved from "https://proteopedia.org/4zcf"