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==Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a ligand==
==Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a ligand==
<StructureSection load='5d7d' size='340' side='right' caption='[[5d7d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5d7d' size='340' side='right'caption='[[5d7d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5d7d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7D FirstGlance]. <br>
<table><tr><td colspan='2'>[[5d7d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D7D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=57X:7-PROPYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-1,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>57X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=57X:7-PROPYL-3-[2-(PYRIDIN-3-YL)-1,3-THIAZOL-5-YL]-1,7-DIHYDRO-6H-PYRAZOLO[3,4-B]PYRIDIN-6-ONE'>57X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cph|5cph]], [[5ctu|5ctu]], [[5ctw|5ctw]], [[5ctx|5ctx]], [[5cty|5cty]], [[5d6p|5d6p]], [[5d6q|5d6q]], [[5d7c|5d7c]], [[5d7r|5d7r]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7d OCA], [https://pdbe.org/5d7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d7d RCSB], [https://www.ebi.ac.uk/pdbsum/5d7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7d ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7d OCA], [http://pdbe.org/5d7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7d RCSB], [http://www.ebi.ac.uk/pdbsum/5d7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]  
[https://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5d7d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5d7d" style="background-color:#fffaf0;"></div>
==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Andersen, O A]]
[[Category: Large Structures]]
[[Category: Barker, J]]
[[Category: Staphylococcus aureus]]
[[Category: Cheng, R K]]
[[Category: Andersen OA]]
[[Category: Cross, J B]]
[[Category: Barker J]]
[[Category: Dolle, R E]]
[[Category: Cheng RK]]
[[Category: Felicetti, B]]
[[Category: Cross JB]]
[[Category: Kahmann, J]]
[[Category: Dolle RE]]
[[Category: Lippa, B]]
[[Category: Felicetti B]]
[[Category: Romero, J A.C]]
[[Category: Kahmann J]]
[[Category: Ryan, M D]]
[[Category: Lippa B]]
[[Category: Scheich, C]]
[[Category: Romero JAC]]
[[Category: Wood, M]]
[[Category: Ryan MD]]
[[Category: Yang, Q]]
[[Category: Scheich C]]
[[Category: Zhang, J]]
[[Category: Wood M]]
[[Category: Dna gyrase]]
[[Category: Yang Q]]
[[Category: Gyrb]]
[[Category: Zhang J]]
[[Category: Isomerase-isomerase inhibitor complex]]
[[Category: Ligand]]
[[Category: Structure-based design]]

Revision as of 10:24, 21 June 2023

Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a ligand

5d7d, resolution 1.60Å

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