Plexin

spinqualitylabelsall models Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Plexin (PLX) is the receptor for semaphorin. Plexin A controls axon guidance. Plexin B regulates Rho GTPase. Plexin C is the receptor for GPI-anchored semaphorin Sema7A. Structural highlights Plexin C1 interactions with semaphoric SEMA7A. Water molecules are shown as red spheres. Ca coordination site. 3D structures of plexin Plexin 3D structures

3D structures of plexin

03-September-2023

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• Plexin A
  • Plexin 3D structures, 5l59, 5l5c – mPLX-A1 extracellular domain segment 1-10 - mouse
    
  • 5l7n – mPLX-A1 extracellular domain segment 7-10
    
  • 3ryt - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate
    
  • 3q3j - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human
    
  • 3al8, 3oky – mPLX-A2 + semaphorin-6A
    
  • 4gza - mPLX-A2 + semaphorin-3A + neuropilin-1
    
  • 3al9 – mPLX-A2 SEMA+PSI domain
    
  • 3okt - mPLX-A2 extracellular domain segment 1-4
    
  • 5l5g – mPLX-A2 extracellular domain segment 1-8
    
  • 5l74 – mPLX-A2 extracellular domain segment 4-5
    
  • 3ig3 - mPLX-A3 intracellular domain
    
  • 4e74 - hPLX-A4 Rho GTPase-binding domain
    
  • 5l5k, 5l5l – mPLX-A4 extracellular domain
    
  • 5l5k – mPLX-A4 extracellular domain segment 1-10
    
  • 5l5l – mPLX-A4 extracellular domain segment 1-8
    
  • 5l5m, 5l5n – mPLX-A4 extracellular domain segment 1-7
    
  • 7m0r – mPLX-A4 + neuropilin + semaphorin - CryoEM
    
  • 6fkm, 6fkn - PLX-A + semaphoring – Drosophila melanogaster
    
• Plexin B
  • 2r2o – hPLX-B1 effector domain
  • 2rex - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
  • 2jph - hPLX-B1 effector domain – NMR
    
  • 3ol2 - hPLX-B1 + semaphorin 4D
  • 3sua, 3su8 – hPLX-B1 + RAS-related C3 botulinum toxin substrate
  • 3hm6 - hPLX-B1 cytoplasmic domain + peptide
    
  • 5b4w - hPLX-B1 residues 20-535 + peptide inhibitor
    
  • 4e71 - hPLX-B2 effector domain
    
  • 5e6p - hPLX-B2 cytoplasmic domain + Rho guanine nucleotide exchange factor 11
    
  • 7kdc – mPLX-B2 receptor binding domain 1463-1565 + RhoD
    
• Plexin C
  • 3kuz - hPLX-C1 ubiquitin-like domain
  • 3nvn, 3nvq – hPLX-C1 + semaphorin 7A
    
  • 6vxk - hPLX-C1 + semaphorin-like protein – Cryo EM
    
  • 4m8n - PLX-C1 intracellular domain + RAP1B – zebra fish
    
• Plexin D
  • 3h6n - hPLX-D1 ubiquitin-like domain
    
  • 5v6r - mPLX-D1 intracellular domain
    
  • 5v6t - mPLX-D1 intracellular domain + GIPC1
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman