3fkt: Difference between revisions
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<StructureSection load='3fkt' size='340' side='right'caption='[[3fkt]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3fkt' size='340' side='right'caption='[[3fkt]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3fkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3fkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3e3w 3e3w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SII:N-(4-{[4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-2-OXO-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-8-YL]METHYL}PHENYL)ACETAMIDE'>SII</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SII:N-(4-{[4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-2-OXO-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-8-YL]METHYL}PHENYL)ACETAMIDE'>SII</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fkt OCA], [https://pdbe.org/3fkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fkt RCSB], [https://www.ebi.ac.uk/pdbsum/3fkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fkt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fkt OCA], [https://pdbe.org/3fkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fkt RCSB], [https://www.ebi.ac.uk/pdbsum/3fkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fkt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Munshi S]] | |||
[[Category: Munshi | |||
Latest revision as of 06:47, 6 September 2023
Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
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