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==Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins==
==Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins==
<StructureSection load='3mmp' size='340' side='right' caption='[[3mmp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3mmp' size='340' side='right'caption='[[3mmp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mmp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Allolevivirus_subgroup_iii Allolevivirus subgroup iii] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMP FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_virus_Qbeta Escherichia virus Qbeta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MMP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PXN:(2S)-1-[3-{[(2R)-2-HYDROXYPROPYL]OXY}-2,2-BIS({[(2R)-2-HYDROXYPROPYL]OXY}METHYL)PROPOXY]PROPAN-2-OL'>PXN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tufB, b3980, JW3943, tsf, b0170, JW0165 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PXN:(2S)-1-[3-{[(2R)-2-HYDROXYPROPYL]OXY}-2,2-BIS({[(2R)-2-HYDROXYPROPYL]OXY}METHYL)PROPOXY]PROPAN-2-OL'>PXN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmp OCA], [https://pdbe.org/3mmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mmp RCSB], [https://www.ebi.ac.uk/pdbsum/3mmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmp OCA], [http://pdbe.org/3mmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mmp RCSB], [http://www.ebi.ac.uk/pdbsum/3mmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/EFTS_ECOLI EFTS_ECOLI]] Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.[HAMAP-Rule:MF_00050] [[http://www.uniprot.org/uniprot/RDRP_BPQBE RDRP_BPQBE]] This enzyme is part of the viral RNA-dependent RNA polymerase complex.  
[https://www.uniprot.org/uniprot/RDRP_BPQBE RDRP_BPQBE] This enzyme is part of the viral RNA-dependent RNA polymerase complex.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mm/3mmp_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mm/3mmp_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3mmp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3mmp" style="background-color:#fffaf0;"></div>
==See Also==
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Allolevivirus subgroup iii]]
[[Category: Escherichia coli K-12]]
[[Category: Ecoli]]
[[Category: Escherichia virus Qbeta]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Large Structures]]
[[Category: Andersen, G R]]
[[Category: Andersen GR]]
[[Category: Chetverin, A B]]
[[Category: Chetverin AB]]
[[Category: Kidmose, R T]]
[[Category: Kidmose RT]]
[[Category: Knudsen, C R]]
[[Category: Knudsen CR]]
[[Category: Vasiliev, N N]]
[[Category: Vasiliev NN]]
[[Category: Host-factor complex]]
[[Category: Rdrp]]
[[Category: Transferase]]
[[Category: Translation]]
Retrieved from "https://proteopedia.org/3mmp"