6ash: Difference between revisions
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<StructureSection load='6ash' size='340' side='right'caption='[[6ash]], [[Resolution|resolution]] 1.42Å' scene=''> | <StructureSection load='6ash' size='340' side='right'caption='[[6ash]], [[Resolution|resolution]] 1.42Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6ash]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6ash]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ASH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ASH FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.423Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XF:2-{[(CARBAMOYLSULFANYL)ACETYL]AMINO}BENZOIC+ACID'>1XF</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ash FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ash OCA], [https://pdbe.org/6ash PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ash RCSB], [https://www.ebi.ac.uk/pdbsum/6ash PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ash ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aguda | [[Category: Aguda A]] | ||
[[Category: Brayer | [[Category: Brayer G]] | ||
[[Category: Bromme | [[Category: Bromme D]] | ||
[[Category: Law | [[Category: Law S]] | ||
[[Category: Nguyen | [[Category: Nguyen N]] | ||
Latest revision as of 14:24, 4 October 2023
Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution
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