3vx8: Difference between revisions

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<StructureSection load='3vx8' size='340' side='right'caption='[[3vx8]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
<StructureSection load='3vx8' size='340' side='right'caption='[[3vx8]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vx8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VX8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vx8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VX8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vx6|3vx6]], [[3vx7|3vx7]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATG7, APG7, At5g45900, K15I22.10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), ATG3, APG3, At5g61500, K11J9.3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vx8 OCA], [https://pdbe.org/3vx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vx8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vx8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vx8 OCA], [https://pdbe.org/3vx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vx8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vx8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ATG7_ARATH ATG7_ARATH]] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process.<ref>PMID:12070171</ref> [[https://www.uniprot.org/uniprot/ATG3_ARATH ATG3_ARATH]] E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).
[https://www.uniprot.org/uniprot/ATG7_ARATH ATG7_ARATH] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process.<ref>PMID:12070171</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fujioka, Y]]
[[Category: Fujioka Y]]
[[Category: Matoba, K]]
[[Category: Matoba K]]
[[Category: Noda, N N]]
[[Category: Noda NN]]
[[Category: E1-e2 complex]]
[[Category: Ligase]]

Latest revision as of 14:13, 18 October 2023

Crystal structure of Arabidopsis thaliana Atg7NTD-Atg3 complex

3vx8, resolution 3.11Å

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