7m40: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)== | ==Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)== | ||
<StructureSection load='7m40' size='340' side='right'caption='[[7m40]]' scene=''> | <StructureSection load='7m40' size='340' side='right'caption='[[7m40]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M40 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7m40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M40 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m40 OCA], [https://pdbe.org/7m40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m40 RCSB], [https://www.ebi.ac.uk/pdbsum/7m40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m40 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YQJ:N~3~-{4-[3-(dimethylamino)pyrrolidin-1-yl]-6,7-dimethoxyquinazolin-2-yl}-N~1~,N~1~-dimethylpropane-1,3-diamine'>YQJ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m40 OCA], [https://pdbe.org/7m40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m40 RCSB], [https://www.ebi.ac.uk/pdbsum/7m40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m40 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | |||
==See Also== | |||
*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abbey M]] | [[Category: Abbey M]] | ||
Latest revision as of 16:05, 18 October 2023
Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)
| ||||||||||||
