3r45: Difference between revisions

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<StructureSection load='3r45' size='340' side='right'caption='[[3r45]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3r45' size='340' side='right'caption='[[3r45]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3r45]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R45 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3r45]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R45 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CENPA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HJURP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r45 OCA], [https://pdbe.org/3r45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r45 RCSB], [https://www.ebi.ac.uk/pdbsum/3r45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r45 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r45 OCA], [https://pdbe.org/3r45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r45 RCSB], [https://www.ebi.ac.uk/pdbsum/3r45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r45 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref>  [[https://www.uniprot.org/uniprot/HJURP_HUMAN HJURP_HUMAN]] Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.<ref>PMID:19410544</ref> <ref>PMID:19410545</ref>
[https://www.uniprot.org/uniprot/HJURP_HUMAN HJURP_HUMAN] Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.<ref>PMID:19410544</ref> <ref>PMID:19410545</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fang, J]]
[[Category: Fang J]]
[[Category: Hu, H]]
[[Category: Hu H]]
[[Category: Huang, H]]
[[Category: Huang H]]
[[Category: Li, G]]
[[Category: Li G]]
[[Category: Li, Y]]
[[Category: Li Y]]
[[Category: Liu, Y]]
[[Category: Liu Y]]
[[Category: Shi, Y]]
[[Category: Shi Y]]
[[Category: Wang, J]]
[[Category: Wang J]]
[[Category: Wang, M]]
[[Category: Wang M]]
[[Category: Xu, R M]]
[[Category: Xu RM]]
[[Category: Yang, N]]
[[Category: Yang N]]
[[Category: Yao, X]]
[[Category: Yao X]]
[[Category: Cenp-a]]
[[Category: Centromere]]
[[Category: Histone chaperone]]
[[Category: Histone fold]]
[[Category: Hjurp]]
[[Category: Nuclear protein]]

Latest revision as of 17:15, 1 November 2023

Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP

3r45, resolution 2.60Å

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