Sequestosome

spinqualitylabelsall models Structure of human sequestosome UBA domain (PDB code 2jy8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sequestosome (SQS) or p62, is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination. Structural highlights SQS is a multi-domain protein. SQS domain structure includes: PB1 domain which contains Phox and Berm1 ZZ-type zinc finger SMIR – SOD interaction domain TB – TRAF6 binding motif LC3 – microtubule-associated protein 1 light chain 3B LIR – interaction region UBA – ubiquitin association domain. Relevance SQS is associated with fibrillary tangles in Alzheimer disease. 3D structures of sequestosome Updated on 15-November-2023 Domains: PB1 1-102; ZZ 120-180; UBA 387-436 1q02, 2jy7, 2jy8, 2k0b, 2knv – hSQS UBA domain – human - NMR 6jm4 – hSQS-1 PB1 domain (mutant) 4uf8, 4uf9, 6tgy, 6th3 – hSQS-1 PB1 domain – Cryo EM 5yp7, 5yp8, 5ypa, 5ypb, 5ypc, 5ype, 5ypg, 5yph, 5ypi, 6miu – hSQS-1 ZZ domain 6mj7 – hSQS-1 ZZ domain + Arg 6khz – hSQS-1 ZZ domain + Gly 7r1o – hSQS-1 ZZ domain + drug 2ktr – rSQS PB1 domain – rat - NMR 2kkc – rSQS PB1 domain (mutant) - NMR 4mjs – hSQS-1 PB1 domain + protein kinase C zeta type 3b0f – mSQS UBA domain – mouse 2rru – mSQS UBA domain - NMR

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Michal Harel