1odz: Difference between revisions

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<StructureSection load='1odz' size='340' side='right'caption='[[1odz]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='1odz' size='340' side='right'caption='[[1odz]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1odz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ODZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1odz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ODZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">manA, man26A, CJA_2770 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=155077 "Cellvibrio cellulosa" Nagy et al. 2002])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannan_endo-1,4-beta-mannosidase Mannan endo-1,4-beta-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.78 3.2.1.78] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1odz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1odz OCA], [https://pdbe.org/1odz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1odz RCSB], [https://www.ebi.ac.uk/pdbsum/1odz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1odz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1odz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1odz OCA], [http://pdbe.org/1odz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1odz RCSB], [http://www.ebi.ac.uk/pdbsum/1odz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1odz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MANA_CELJU MANA_CELJU]] Hydrolyzes mannan and galactomannan, but displays little activity towards other polysaccharides located in the plant cell wall. Appears to act in synergy with alpha-galactosidase (AgaA) to elicit hydrolysis of galactomannan. Preferentially hydrolyzes the larger oligosaccharides and has greater activity against non-substituted polysaccharides.<ref>PMID:7848261</ref> <ref>PMID:11064195</ref>
[https://www.uniprot.org/uniprot/MANA_CELJU MANA_CELJU] Hydrolyzes mannan and galactomannan, but displays little activity towards other polysaccharides located in the plant cell wall. Appears to act in synergy with alpha-galactosidase (AgaA) to elicit hydrolysis of galactomannan. Preferentially hydrolyzes the larger oligosaccharides and has greater activity against non-substituted polysaccharides.<ref>PMID:7848261</ref> <ref>PMID:11064195</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cellvibrio cellulosa nagy et al. 2002]]
[[Category: Cellvibrio japonicus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mannan endo-1,4-beta-mannosidase]]
[[Category: Davies GJ]]
[[Category: Davies, G J]]
[[Category: Ducros VMA]]
[[Category: Ducros, V M.A]]
[[Category: Gilbert HJ]]
[[Category: Gilbert, H J]]
[[Category: Jahn M]]
[[Category: Jahn, M]]
[[Category: Singh P]]
[[Category: Singh, P]]
[[Category: Stoll D]]
[[Category: Stoll, D]]
[[Category: Szabo L]]
[[Category: Szabo, L]]
[[Category: Warren RAJ]]
[[Category: Warren, R A.J]]
[[Category: Withers SG]]
[[Category: Withers, S G]]
[[Category: Family 26]]
[[Category: Glycoside-hydrolase]]
[[Category: Glycosynthase]]
[[Category: Hydrolase]]
[[Category: Mannanase]]
[[Category: Manno-oligosaccharide]]

Latest revision as of 12:37, 13 December 2023

Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides

1odz, resolution 1.40Å

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