6sdf: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='6sdf' size='340' side='right'caption='[[6sdf]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='6sdf' size='340' side='right'caption='[[6sdf]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6sdf]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6sdf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SDF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sdf OCA], [https://pdbe.org/6sdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sdf RCSB], [https://www.ebi.ac.uk/pdbsum/6sdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sdf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 6sdf" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6sdf" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bezprozvanny | [[Category: Bezprozvanny IB]] | ||
[[Category: Bolgov | [[Category: Bolgov AA]] | ||
[[Category: Kim | [[Category: Kim M]] | ||
[[Category: Korban | [[Category: Korban SA]] | ||
[[Category: Luzik | [[Category: Luzik DA]] | ||
[[Category: Rogacheva | [[Category: Rogacheva ON]] | ||
[[Category: Skrynnikov | [[Category: Skrynnikov NR]] | ||
[[Category: Zhemkov | [[Category: Zhemkov VA]] | ||
Latest revision as of 12:39, 24 January 2024
N-terminal SH3 domain of Grb2 protein
| ||||||||||||
