Growth factor receptor-bound proteins 3D structures

3D structures of growth factor receptor-bound proteins

Updated on 31-July-2025

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• GRB2
  • 1gri, 2h46 – hGRB2 – human
    
  • 8dgo – hGRB2 + PEAK3 peptide
    
• GRB2 N terminal SH3 domain residues 1-61
  • 6sdf – hGRB2 N terminal SH3 domain
    
  • 1gbq, 1gbr, 2gbq, 3gbq, 4gbq – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR
    
  • 1aze – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR
    
• GRB2 C terminal SH3 domain residues 159-214
  • 1gfc, 1gfd – hGRB2 C terminal SH3 domain - NMR
    
  • 2vvk, 2vwf, 2w0z – hGRB2 C terminal SH3 domain
    
  • 1io6 – hGRB2 C terminal SH3 domain + ligand peptide - NMR
    
  • 1gcq – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain
    
  • 7y4n – DmGRB2 C terminal SH3 domain – Drosophila melanogaster - NMR
    
• GRB2 SH2 domain residues 60-158
  • 1jyu, 6icg, 6ich – hGRB2 SH2 domain
    
  • 1ghu – hGRB2 SH2 domain (mutant) - NMR
    
  • 1fhs, 6vk2 – hGRB2 SH2 domain - NMR
    
  • 7mph – hGRB2 SH2 domain + inhibitor
    
  • 1x0n – hGRB2 SH2 domain + inhibitor - NMR
    
  • 2huw – hGRB2 SH2 domain + cyclopropane derivative
    
  • 1cj1 – hGRB2 SH2 domain + phosphor-Tyr derivative
    
  • 2aoa, 2aob – hGRB2 SH2 domain + peptide mimetic
    
  • 1bm2, 1bmb, 1fyr, 1jyq, 1jyr, 1tze, 1zfp, 2h5k, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3mxc, 3mxy, 3n7y, 3n84, 3n8m, 3ov1, 3ove, 3s8l, 3s8n, 3s8o, 4p9v, 4p9z, 6wm1, 6wo2 – hGRB2 SH2 domain + phosphor-Tyr peptide
    
  • 5cdw – hGRB2 SH2 domain (mutant) + phosphor-Tyr peptide
    
  • 1qg1 – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR
    
  • 3wa4 - hGRB2 SH2 domain + CD28 peptide
    
  • 8z0n – DmGRB SH2 domain - NMR
    
• GRB4
  • 4e6r – hGRB4 C terminal SH3 domain
    
• GRB7
  • 2qms, 4wwq – hGRB7 SH2 domain
    
  • 4x6s, 5d0j, 5eel, 5eeq – hGRB7 SH2 domain + phosphor-Tyr peptide
    
  • 1mw4, 2l4k – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR
    
  • 3pqz, 5tyi, 5u06, 5u1q, 7mp3 – hGRB7 SH2 domain + cyclic peptide
    
  • 1wgr – hGRB7 RA domain residues 100-186 - NMR
    
• GRB10
  • 1nrv – hGRB10 SH2 domain
    
  • 3m7f – hGRB10 SH2 domain + NEDD4 C2 domain
    
  • 3hk0 – hGRB10 PH domain residues 164-415
    
• GRB14
  • 2aug – hGRB14 SH2 domain
    
  • 2auh – hGRB14 BPS domain residues 361-419 + insulin receptor kinase domain
    
  • 4k81 – hGRB14 PH domain + GTPase Hras
    

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Michal Harel