7o4d: Difference between revisions
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==QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline== | ==QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline== | ||
<StructureSection load='7o4d' size='340' side='right'caption='[[7o4d]]' scene=''> | <StructureSection load='7o4d' size='340' side='right'caption='[[7o4d]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O4D FirstGlance]. <br> | <table><tr><td colspan='2'>[[7o4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O4D FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o4d OCA], [https://pdbe.org/7o4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o4d RCSB], [https://www.ebi.ac.uk/pdbsum/7o4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o4d ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.249Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V1Z:8-methyl-2-(4-methyl-3-piperazin-1-ylsulfonyl-phenyl)imidazo[1,2-a]pyridine'>V1Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o4d OCA], [https://pdbe.org/7o4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o4d RCSB], [https://www.ebi.ac.uk/pdbsum/7o4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o4d ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Albeck S]] | [[Category: Albeck S]] | ||
