3q3j: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[3q3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3Q3J FirstGlance].

<table><tr><td colspan='2'>[[3q3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3Q3J FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>~~</td></tr>~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.971Å</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RND1, RHO6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3q3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3j OCA], [https://pdbe.org/3q3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3j RCSB], [https://www.ebi.ac.uk/pdbsum/3q3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3j ProSAT]</td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/PLXA2_HUMAN PLXA2_HUMAN]] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). [[https://www.uniprot.org/uniprot/RND1_HUMAN RND1_HUMAN]] Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.<ref>PMID:11095956</ref>

[https://www.uniprot.org/uniprot/PLXA2_HUMAN PLXA2_HUMAN] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

==See Also==

*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]

*[[Plexin|Plexin]]

*[[Plexin 3D structures|Plexin 3D structures]]

*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]

~~== References ==~~

~~<references/>~~

__TOC__

</StructureSection>

[[Category: ~~Human~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith~~, C H~~]]

[[Category: Arrowsmith CH]]

[[Category: Bountra, C]]

[[Category: Bountra C]]

[[Category: Buren, L]]

[[Category: Buren L]]

[[Category: Crombet, L]]

[[Category: Crombet L]]

[[Category: Edwards~~, A M~~]]

[[Category: Edwards AM]]

[[Category: Guan, X]]

[[Category: Guan X]]

[[Category: Park, H]]

[[Category: Park H]]

~~[[Category: Structural genomic~~]]

[[Category: Shen L]]

[[Category: Shen, L]]

[[Category: Tempel W]]

[[Category: Tempel, W]]

[[Category: Tong Y]]

[[Category: Tong, Y]]

[[Category: Wang H]]

[[Category: Wang, H]]

[[Category: Weigelt J]]

[[Category: Weigelt, J]]

[[Category: Wernimont AK]]

[[Category: Wernimont~~, A K~~]]

[[Category: Zhang N]]

[[Category: Zhang, N]]

~~[[Category: Membrane protein-protein binding complex]]~~

~~[[Category: Plexin]]~~

~~[[Category: Ras-binding domain]]~~

~~[[Category: Sgc]]~~

~~[[Category: Small gtpase~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='3q3j' size='340' side='right'caption='[[3q3j]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3q3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3J FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3q3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3J FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.971&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RND1, RHO6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3j OCA], [https://pdbe.org/3q3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3j RCSB], [https://www.ebi.ac.uk/pdbsum/3q3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3j ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/PLXA2_HUMAN PLXA2_HUMAN]] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). [[https://www.uniprot.org/uniprot/RND1_HUMAN RND1_HUMAN]] Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.<ref>PMID:11095956</ref>
+[https://www.uniprot.org/uniprot/PLXA2_HUMAN PLXA2_HUMAN] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
 ==See Also==
 *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
-*[[Plexin|Plexin]]
+*[[Plexin 3D structures|Plexin 3D structures]]
 *[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C]]
+[[Category: Bountra C]]
-[[Category: Buren, L]]
+[[Category: Buren L]]
-[[Category: Crombet, L]]
+[[Category: Crombet L]]
-[[Category: Edwards, A M]]
+[[Category: Edwards AM]]
-[[Category: Guan, X]]
+[[Category: Guan X]]
-[[Category: Park, H]]
+[[Category: Park H]]
-[[Category: Structural genomic]]
+[[Category: Shen L]]
-[[Category: Shen, L]]
+[[Category: Tempel W]]
-[[Category: Tempel, W]]
+[[Category: Tong Y]]
-[[Category: Tong, Y]]
+[[Category: Wang H]]
-[[Category: Wang, H]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J]]
+[[Category: Wernimont AK]]
-[[Category: Wernimont, A K]]
+[[Category: Zhang N]]
-[[Category: Zhang, N]]
-[[Category: Membrane protein-protein binding complex]]
-[[Category: Plexin]]
-[[Category: Ras-binding domain]]
-[[Category: Sgc]]
-[[Category: Small gtpase]]