6zy5: Difference between revisions

Line 1:

====

==Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance].

<table><tr><td colspan='2'>[[6zy5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZY5 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6ZY5 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6zy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zy5 OCA], [https://pdbe.org/6zy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zy5 RCSB], [https://www.ebi.ac.uk/pdbsum/6zy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zy5 ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVP:(5S,5AR,8AR,9R)-9-(4-HYDROXY-3,5-DIMETHOXYPHENYL)-8-OXO-5,5A,6,8,8A,9-HEXAHYDROFURO[3,4 6,7]NAPHTHO[2,3-D][1,3]DIOXOL-5-YL+4,6-O-[(1R)-ETHYLIDENE]-BETA-D-GLUCOPYRANOSIDE'>EVP</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6zy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zy5 OCA], [https://pdbe.org/6zy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zy5 RCSB], [https://www.ebi.ac.uk/pdbsum/6zy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zy5 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TOP2A_HUMAN TOP2A_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:22323612</ref>

==See Also==

*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: ~~Z-disk~~]]

[[Category: Lamour V]]

[[Category: Vanden Broeck A]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-====
+==Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1==
-<StructureSection load='6zy5' size='340' side='right'caption='[[6zy5]]' scene=''>
+<StructureSection load='6zy5' size='340' side='right'caption='[[6zy5]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6zy5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZY5 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zy5 OCA], [https://pdbe.org/6zy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zy5 RCSB], [https://www.ebi.ac.uk/pdbsum/6zy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zy5 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVP:(5S,5AR,8AR,9R)-9-(4-HYDROXY-3,5-DIMETHOXYPHENYL)-8-OXO-5,5A,6,8,8A,9-HEXAHYDROFURO[3,4 6,7]NAPHTHO[2,3-D][1,3]DIOXOL-5-YL+4,6-O-[(1R)-ETHYLIDENE]-BETA-D-GLUCOPYRANOSIDE'>EVP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zy5 OCA], [https://pdbe.org/6zy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zy5 RCSB], [https://www.ebi.ac.uk/pdbsum/6zy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zy5 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/TOP2A_HUMAN TOP2A_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:22323612</ref>
+==See Also==
+*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Lamour V]]
+[[Category: Vanden Broeck A]]