6zy5

Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1

spinqualitylabelsall models 6zy5, resolution 3.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6zy5 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.6Å Ligands: EVP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TOP2A_HUMAN Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. See Also Topoisomerase 3D structures

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