2jv4: Difference between revisions

Latest revision as of 19:06, 29 May 2024

Structure Characterisation of PINA WW Domain and Comparison with other Group IV WW Domains, PIN1 and ESS1

Structural highlights

2jv4 is a 1 chain structure with sequence from Aspergillus nidulans. This structure supersedes the now removed PDB entry 2jm7. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O42735_EMEND

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The NMR solution structure of the PinA WW domain from Aspergillus nidulans is presented. The backbone of the PinA WW domain is composed of a triple-stranded anti-parallel beta-sheet and an alpha-helix similar to Ess1 and Pin1 without the alpha-helix linker. Large RMS deviations in Loop I were observed both from the NMR structures and molecular dynamics simulation suggest that the Loop I of PinA WW domain is flexible and solvent accessible, thus enabling it to bind the pS/pT-P motif. The WW domain in this structure are stabilised by a hydrophobic core. It is shown that the linker flexibility of PinA is restricted because of an alpha-helical structure in the linker region. The combination of NMR structural data and detailed Molecular Dynamics simulations enables a comprehensive structural and dynamic understanding of this protein.

Structural characterisation of PinA WW domain and a comparison with other group IV WW domains, Pin1 and Ess1.,Ng CA, Kato Y, Tanokura M, Brownlee RT Biochim Biophys Acta. 2008 Sep;1784(9):1208-14. Epub 2008 May 8. PMID:18503784^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ng CA, Kato Y, Tanokura M, Brownlee RT. Structural characterisation of PinA WW domain and a comparison with other group IV WW domains, Pin1 and Ess1. Biochim Biophys Acta. 2008 Sep;1784(9):1208-14. Epub 2008 May 8. PMID:18503784 doi:10.1016/j.bbapap.2008.04.026

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OCA

[1] Ng CA, Kato Y, Tanokura M, Brownlee RT. Structural characterisation of PinA WW domain and a comparison with other group IV WW domains, Pin1 and Ess1. Biochim Biophys Acta. 2008 Sep;1784(9):1208-14. Epub 2008 May 8. PMID:18503784 doi:10.1016/j.bbapap.2008.04.026

[1]

@@ Line 1: / Line 1: @@
 ==Structure Characterisation of PINA WW Domain and Comparison with other Group IV WW Domains, PIN1 and ESS1==
-<StructureSection load='2jv4' size='340' side='right'caption='[[2jv4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2jv4' size='340' side='right'caption='[[2jv4]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/A._nidulans A. nidulans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jm7 2jm7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JV4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jm7 2jm7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JV4 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pinA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=162425 A. nidulans])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jv4 OCA], [https://pdbe.org/2jv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jv4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jv4 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/O42735_EMEND O42735_EMEND]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: A. nidulans]]
+[[Category: Aspergillus nidulans]]
 [[Category: Large Structures]]
-[[Category: Peptidylprolyl isomerase]]
+[[Category: Brownlee RTC]]
-[[Category: Brownlee, R T.C]]
+[[Category: Kato Y]]
-[[Category: Kato, Y]]
+[[Category: Ng CA]]
-[[Category: Ng, C A]]
+[[Category: Tanokura M]]
-[[Category: Tanokura, M]]
-[[Category: Isomerase]]
-[[Category: Ppiase domain]]
-[[Category: Rotamase]]
-[[Category: Ww domain group iv]]

2jv4: Difference between revisions

Latest revision as of 19:06, 29 May 2024

Structure Characterisation of PINA WW Domain and Comparison with other Group IV WW Domains, PIN1 and ESS1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

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