Peptidyl-prolyl cis-trans isomerase 3D structures

3D Structures of peptidyl-prolyl cis-trans isomerase

Updated on 19-May-2026

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• PPIase
  • 8ro0 – PPIase in spliceosome – Caenoerhabditis elegans – Cryo EM
    
  • 9l5r, 9l5s, 9l5t – ThtPPIase in spliceosome – Thermochaetoides thermophila – Cryo EM
    
  • 9g6k, 9i05 – PPIase in mitoribosome – Toxoplasma gondii – Cryo EM
    
  • 9grx – PPIase in NDH-PSI-LHCI complex – spinach - Cryo EM
    
  • 6hmz – PPIase + cyclosporin – rape
    
  • 3k2c – PPIase – Encephalitozoon cuniculi
    
  • 1yw5 – PPIase – Candida albicans
    
  • 9ls5 – PPIase – Entamoeba hysolytica
    
  • 2mc9 – PPIase – rosy periwinkle - NMR
    
  • 2wlw – PPIase CypA domain – Macaca mulatta
    
  • 5xb0 – PPIase – Pseudomonas syringae
    
  • 4s1e, 4s1j, 6l2b – PPIase (mutant) – Leishmania donovani
    
  • 2m08 – PPIase – Nitrosopumilus maritimus - NMR
    
  • 6h3j, 8gl6, 8gl8, 8glj, 8glk, 8glm, 8gln – FjPPIase in secretion system complex – Flavobacterium johnsoniae – Cryo EM
    
  • 6lxo, 6lxp, 6lxq, 6lxr – PPIase – Trichomonas vaginalis
    
  • 7l6y – PPIase – Streptococcus pyogenes
    
  • 7l6z – PPIase – Streptococcus pneumoniae
    
  • 7n3j, 7rfd – EcPPIase (mutant) – Escherichia coli
    
  • 8zht – BtPPIase + tetratricopeptide repeat protein – Bacterioides thetaiotamicron
    
  • 9his – BtPPIase in BAM complex – Cryo EM
    
  • 9hjm – PPIase in BAM complex – Porphyromonas gingivalis - Cryo EM
    
• PPIase Pin1; Domains – WW 1-39; PPIase 51-163
  • 1pin, 6dun, 6o33, 6o34, 6vaj, 7efj – hPin1 – human
    
  • 1nmv, 7sa5, 7suq, 7sur – hPin1 - NMR
    
  • 1zcn, 2zqs, 2zqt, 2zqu, 2zqv, 2zr4, 2zr5, 2zr6 – hPin1 (mutant)
    
  • 9it1 – hPin1 - Laue
    
  • 1i6c, 2kcf, 1eq3, 2m8i, 2m8j – hPin1 WW domain - NMR
    
  • 2f21, 1fjd, 2m9e, 2m9f, 2m9i, 2m9j, 5vti, 5vtj, 5vtk, 6svc, 6sve, 6svh – hPin1 WW domain (mutant)
    
  • 3ik8 – hPin1 PPIase domain (mutant)
    
  • 2rud, 2ruq, 2rur, 5gph – hPin1 PPIase domain (mutant) - NMR
    
  • 1nmw, 2ruc – hPin1 PPIase domain - NMR
    
  • 1j6y – AtPin1 – Arabidopsis thaliana - NMR
    
• PPIase Pin1 complexes
  • 1f8a, 5uy9 – hPin1 + phosphoserine containing peptide
    
  • 8sg2 – hPin1 + peptide
    
  • 8vjd, 8vje, 8vjf, 8vjg – hPin1 (mutant) + peptide inhibitor
    
  • 8vz3, 8vz5, 8w11 – hPin1 + SuFEx
    
  • 1i8g, 1i8h – hPin1 WW domain + phosphothreoniine containing peptide - NMR
    
  • 2lb3 – hPin1 WW domain + MAD homolog peptide - NMR
    
  • 2n1o – hPin1 WW domain + CPEB1 peptide - NMR
    
  • 4gwt, 4gwv – hPin1 WW domain + small molecule
    
  • 2itk – hPin1 (mutant) + D-peptide
    
  • 2q5a – hPin1 (mutant) + L-peptide
    
  • 4u84, 4u85, 4u86, 7ekv, 7f0m, 9inn, 9ino, 9inp – hPin1 + inhibitor
    
  • 9inq, 9inr, 9jf6, 9jfh, 9jjs, 9jjz, 9jyo, 9jyp, 9jyr, 9jys, 9jyt, 9jyv, 9jz2, 9jz3, 9jz4, 9jz6, 9jzg, 9jzs, 9jzu, 9jzv, 9ke5, 9ke7, 9ke9, 9keb, 9kec, 9kel, 9keq, 9kes, 9kew, 9key, 9kez, 9kf0, 9kfc, 9kfh, 9kfz, 9kgo, 9kx1, 9kx7, 9kx9, 9kxc, 9kxd, 9kxe, 9kxf, 9kxg, 9kxh, 9kxi, 9kxj, 9kxk, 9kxl, 9kxm, 9kxn, 9kxo, 9kxp, 9kxq, 9v92 – hPin1 PPIase domain + inhibitor
    
  • 3ikd, 3ikg, 3kac, 3jyj, 3i6c, 3tc5, 4tyo – hPin1 PPIase domain (mutant) + inhibitor
    
  • 2xp3, 2xp4, 2xp5, 2xp6, 2xp7, 2xp8, 2xp9, 2xpa, 2xpb, 3kab, 3kad, 3kaf, 3kag, 3kah, 3kai, 3kce, 3ntp, 3odk, 3oob, 3tcz, 3tdb, 4qib, 7efx – hPin1 (mutant) + inhibitor
    
  • 4tns – hPin1 PPIase domain (mutant) + retinoic acid
    
  • 3wh0 – hPin1 (mutant) + crown ether
    
  • 3oob – hPin1 (mutant) + dexamethasone phosphate
    
  • 1c5f – Pin1 cyclophilin-like domain + cyclosporine A – Brugia malayi
    
• PPIase Pin4 (Parvulin 14)
  • 3ui4, 3ui5 – hPin4
    
  • 3ui6 – hPin4 + dithiane diol
    
  • 1eq3 – hPin4 PPIase domain - NMR
    
• PPIase PinA
  • 2m1i, 2rqs – PinA – Cenarchaeum symbiosum - NMR
    
• PPIase Cyp7
  • 5jhe – yPPIase – yeast
    
• PPIase Cyp71
  • 6lkb – AtPPIase
    
• PPIase ESSI
  • 7kkf – yPPIase
    
• PPIase Cwc27
  • 4r3e – hPPIase
    
  • 4r3f – ThtPPIase
    
• PPIase Mip
  • 1fd9 – LpMip – Legionella pneumophila
    
  • 8r39 – LpMip (mutant)
    
  • 8bjc, 8bjd, 8bje, 8bk5, 8bk6 – LpMip + inhibitor
    
  • 2y78 – BpMip
    
  • 8p3c – EcMip + inhibitor
    
  • 2vcd – LpMip FKBP domain + rapamycin - NMR
    
  • 1jvw – Mip – Trypanosoma cruzi
    
• PPIase SlyD
  • 2k8i, 2kfw – EcSlyD - NMR
    
  • 2kr7 – FKBP SlyD – NMR - Helicobacter pylori
    
  • 3cgm, 3cgn – TtSlyD – Thermus thermophilus
    
  • 3luo – TtSlyD + peptide
    
  • 4odk – TtSlyD + RNAse T1 peptide
    
  • 4odl, 4odm, 4odn, 4odp, 7oxg, 7oxh, 7oxi, 7oxj, 7oxk – TtSlyD + RPS2 peptide
    
  • 4odq – TtSlyD + RPS3 peptide
    
  • 4odo – TtSlyD + FK506
    
  • 8g01, 8g02 – EcFKBP-type SlyD + GPE + UDP-murNAc-pentapeptide phosphotransferase– Cryo EM
    
• PPIase SlpA
  • 4dt4 – EcSlpA
    
  • 2m2a – EcSlpA - NMR
    
• PPIase 3 see Cyclophilin-3
  
• PPIase 5 see Cyclophilin-5
  
• PPIase 38 see Cyclophilin-38
  
• PPIase A see Cyclophilin-A
  
• PPIase B see Cyclophilin-B
  
• PPIase C see Cyclophilin-C
  
• PPIase D see Cyclophilin-D
  
• PPIase E see Cyclophilin-E
  
• PPIase F see Cyclophilin-F
  
• PPIase G see Cyclophilin-G
  
• PPIase H see Cyclophilin-H
  
• PPIase FKBP see FK506 binding protein
  

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman