7s0f: Difference between revisions
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==== | ==Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein== | ||
<StructureSection load='7s0f' size='340' side='right'caption='[[7s0f]]' scene=''> | <StructureSection load='7s0f' size='340' side='right'caption='[[7s0f]], [[Resolution|resolution]] 2.96Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7s0f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S0F FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s0f OCA], [https://pdbe.org/7s0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s0f RCSB], [https://www.ebi.ac.uk/pdbsum/7s0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s0f ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.96Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FW:ISOPRENALINE'>5FW</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s0f OCA], [https://pdbe.org/7s0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s0f RCSB], [https://www.ebi.ac.uk/pdbsum/7s0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s0f ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The beta(1)-adrenergic receptor (beta(1)-AR) can activate two families of G proteins. When coupled to Gs, beta(1)-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction. By comparative structural analysis of turkey beta(1)-AR complexed with either Gi or Gs, we investigate how a single G-protein-coupled receptor simultaneously signals through two G proteins. We find that, although the critical receptor-interacting C-terminal alpha5-helices on Galpha(i) and Galpha(s) interact similarly with beta(1)-AR, the overall interacting modes between beta(1)-AR and G proteins vary substantially. Functional studies reveal the importance of the differing interactions and provide evidence that the activation efficacy of G proteins by beta(1)-AR is determined by the entire three-dimensional interaction surface, including intracellular loops 2 and 4 (ICL2 and ICL4). | |||
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR.,Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY Nat Struct Mol Biol. 2021 Nov;28(11):936-944. doi: 10.1038/s41594-021-00679-2. , Epub 2021 Nov 10. PMID:34759376<ref>PMID:34759376</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7s0f" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] | |||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Meleagris gallopavo]] | ||
[[Category: Rattus norvegicus]] | |||
[[Category: Alegre KO]] | |||
[[Category: Eng ET]] | |||
[[Category: Hite RK]] | |||
[[Category: Huang J]] | |||
[[Category: Huang XY]] | |||
[[Category: Jordan KD]] | |||
[[Category: Lou JS]] | |||
[[Category: Meyerson JR]] | |||
[[Category: Paknejad N]] | |||
[[Category: Su M]] | |||
Latest revision as of 11:28, 23 October 2024
Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein
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