8orj: Difference between revisions
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==Cryo-EM structure of human tRNA ligase RTCB in complex with human PYROXD1.== | |||
<StructureSection load='8orj' size='340' side='right'caption='[[8orj]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8orj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ORJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ORJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8orj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8orj OCA], [https://pdbe.org/8orj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8orj RCSB], [https://www.ebi.ac.uk/pdbsum/8orj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8orj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RTCB_HUMAN RTCB_HUMAN] Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.[HAMAP-Rule:MF_03144]<ref>PMID:21311021</ref> <ref>PMID:24870230</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ackle F]] | |||
[[Category: Asanovic I]] | |||
[[Category: Boneberg F]] | |||
[[Category: Ferdigg A]] | |||
[[Category: Jinek M]] | |||
[[Category: Kroupova A]] | |||
[[Category: Loeff L]] | |||
[[Category: Martinez J]] | |||
[[Category: Pfleiderer MM]] | |||
Latest revision as of 06:11, 30 October 2024
Cryo-EM structure of human tRNA ligase RTCB in complex with human PYROXD1.
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