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====
==Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi/s chimera protein==
<StructureSection load='7s0g' size='340' side='right'caption='[[7s0g]]' scene=''>
<StructureSection load='7s0g' size='340' side='right'caption='[[7s0g]], [[Resolution|resolution]] 3.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
<table><tr><td colspan='2'>[[7s0g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S0G FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s0g OCA], [https://pdbe.org/7s0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s0g RCSB], [https://www.ebi.ac.uk/pdbsum/7s0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s0g ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FW:ISOPRENALINE'>5FW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s0g OCA], [https://pdbe.org/7s0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s0g RCSB], [https://www.ebi.ac.uk/pdbsum/7s0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s0g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The beta(1)-adrenergic receptor (beta(1)-AR) can activate two families of G proteins. When coupled to Gs, beta(1)-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction. By comparative structural analysis of turkey beta(1)-AR complexed with either Gi or Gs, we investigate how a single G-protein-coupled receptor simultaneously signals through two G proteins. We find that, although the critical receptor-interacting C-terminal alpha5-helices on Galpha(i) and Galpha(s) interact similarly with beta(1)-AR, the overall interacting modes between beta(1)-AR and G proteins vary substantially. Functional studies reveal the importance of the differing interactions and provide evidence that the activation efficacy of G proteins by beta(1)-AR is determined by the entire three-dimensional interaction surface, including intracellular loops 2 and 4 (ICL2 and ICL4).
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR.,Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY Nat Struct Mol Biol. 2021 Nov;28(11):936-944. doi: 10.1038/s41594-021-00679-2. , Epub 2021 Nov 10. PMID:34759376<ref>PMID:34759376</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7s0g" style="background-color:#fffaf0;"></div>
==See Also==
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Z-disk]]
[[Category: Meleagris gallopavo]]
[[Category: Rattus norvegicus]]
[[Category: Alegre KO]]
[[Category: Eng ET]]
[[Category: Hite RK]]
[[Category: Huang J]]
[[Category: Huang XY]]
[[Category: Jordan KD]]
[[Category: Lou JS]]
[[Category: Meyerson JR]]
[[Category: Paknejad N]]
[[Category: Su M]]
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