8qws: Difference between revisions
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==Crystal structure of CotB2 variant V80L in complex with alendronate== | |||
<StructureSection load='8qws' size='340' side='right'caption='[[8qws]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8qws]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_melanosporofaciens Streptomyces melanosporofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QWS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AHD:4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE'>AHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qws OCA], [https://pdbe.org/8qws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qws RCSB], [https://www.ebi.ac.uk/pdbsum/8qws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qws ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/COTB2_STRMJ COTB2_STRMJ] Catalyzes the cyclization of the linear isoprenoid intermediate geranylgeranyl diphosphate to tricycclic cyclooctat-9-en-7-ol in the cyclooctatin biosynthesis pathway. Cyclooctatin is a potent inhibitor of lysophospholipase.<ref>PMID:19635410</ref> <ref>PMID:24914964</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptomyces melanosporofaciens]] | |||
[[Category: Brueck T]] | |||
[[Category: Dimos N]] | |||
[[Category: Driller R]] | |||
[[Category: Himpich S]] | |||
[[Category: Loll B]] | |||
[[Category: Major DT]] | |||
[[Category: Ringel M]] | |||
Latest revision as of 14:50, 6 November 2024
Crystal structure of CotB2 variant V80L in complex with alendronate
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