8v90: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==TtgR variant 3A7 with naltrexone== | |||
<StructureSection load='8v90' size='340' side='right'caption='[[8v90]], [[Resolution|resolution]] 2.08Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8v90]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida_DOT-T1E Pseudomonas putida DOT-T1E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V90 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YOE:17-(cyclopropylmethyl)-3,14-dihydroxy-5beta,9alpha,13alpha-4,5-epoxymorphinan-6-one'>YOE</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v90 OCA], [https://pdbe.org/8v90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v90 RCSB], [https://www.ebi.ac.uk/pdbsum/8v90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v90 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Lee | == Function == | ||
[https://www.uniprot.org/uniprot/TTGR_PSEPT TTGR_PSEPT] Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.<ref>PMID:11251828</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas putida DOT-T1E]] | |||
[[Category: Acheson JF]] | |||
[[Category: Lee D]] | |||
[[Category: Ramen S]] | |||
