8x4n: Difference between revisions
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==Crystal structure of the PI3P-binding domain of Legionella SetA in complex with inositol 1,3-bisphosphate== | |||
<StructureSection load='8x4n' size='340' side='right'caption='[[8x4n]], [[Resolution|resolution]] 2.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8x4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X4N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ITP:PHOSPHORIC+ACID+MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL)+ESTER'>ITP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x4n OCA], [https://pdbe.org/8x4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x4n RCSB], [https://www.ebi.ac.uk/pdbsum/8x4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x4n ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/SETA_LEGPH SETA_LEGPH] Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 nM), which guides SetA to the cytosolic leaflet of the early phagosome of the host cell.<ref>PMID:19016775</ref> <ref>PMID:22288428</ref> | ||
[[Category: Lee | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Legionella pneumophila]] | |||
[[Category: Hahn H]] | |||
[[Category: Im HN]] | |||
[[Category: Jang DM]] | |||
[[Category: Kim HS]] | |||
[[Category: Lee Y]] | |||
Latest revision as of 14:49, 19 February 2025
Crystal structure of the PI3P-binding domain of Legionella SetA in complex with inositol 1,3-bisphosphate
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