8vtc: Difference between revisions
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==Crystal structure of Mycobacterium avium dihydrofolate reductase in complex with NADPH and trimethoprim== | |||
<StructureSection load='8vtc' size='340' side='right'caption='[[8vtc]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8vtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VTC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vtc OCA], [https://pdbe.org/8vtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vtc RCSB], [https://www.ebi.ac.uk/pdbsum/8vtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vtc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/O30463_MYCAV O30463_MYCAV] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium avium]] | |||
[[Category: Erlandsen H]] | |||
[[Category: Krucinska J]] | |||
[[Category: Wright D]] | |||
Latest revision as of 06:24, 19 March 2025
Crystal structure of Mycobacterium avium dihydrofolate reductase in complex with NADPH and trimethoprim
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