9l0d: Difference between revisions
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==Cryo-EM structure of the human MON1A/CCZ1/C18orf8 complex== | |||
<StructureSection load='9l0d' size='340' side='right'caption='[[9l0d]], [[Resolution|resolution]] 3.41Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9l0d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L0D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l0d OCA], [https://pdbe.org/9l0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l0d RCSB], [https://www.ebi.ac.uk/pdbsum/9l0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l0d ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MON1A_HUMAN MON1A_HUMAN] Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).[UniProtKB:Q6PDG8]<ref>PMID:23084991</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Han Y]] | |||
[[Category: Pan L]] | |||
[[Category: Tang Y]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 06:37, 19 March 2025
Cryo-EM structure of the human MON1A/CCZ1/C18orf8 complex
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