6nep: Difference between revisions
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<StructureSection load='6nep' size='340' side='right'caption='[[6nep]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='6nep' size='340' side='right'caption='[[6nep]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6nep]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6nep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NEP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.097625Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PHI:IODO-PHENYLALANINE'>PHI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nep OCA], [https://pdbe.org/6nep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nep RCSB], [https://www.ebi.ac.uk/pdbsum/6nep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nep ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PACRG_HUMAN PACRG_HUMAN] Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.<ref>PMID:14532270</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Croteau | [[Category: Croteau N]] | ||
[[Category: Khan | [[Category: Khan N]] | ||
[[Category: Pelletier | [[Category: Pelletier D]] | ||
[[Category: Trempe | [[Category: Trempe JF]] | ||
[[Category: Veyron | [[Category: Veyron S]] | ||
Latest revision as of 09:46, 2 April 2025
Structure of human PACRG-MEIG1 complex
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