8w1a: Difference between revisions
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==Cryo-EM Structure of KSHV ORF74 Apo Dimer at 2.8A== | |||
<StructureSection load='8w1a' size='340' side='right'caption='[[8w1a]], [[Resolution|resolution]] 2.89Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8w1a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W1A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.89Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w1a OCA], [https://pdbe.org/8w1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w1a RCSB], [https://www.ebi.ac.uk/pdbsum/8w1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w1a ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VGPCR_HHV8P VGPCR_HHV8P] Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Maintains chronic activation of NF-kappa-B via interaction with host CADM1 (PubMed:29698475).<ref>PMID:12477810</ref> <ref>PMID:14724579</ref> <ref>PMID:29698475</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human gammaherpesvirus 8]] | |||
[[Category: Large Structures]] | |||
[[Category: Dai X]] | |||
[[Category: Jung J]] | |||
[[Category: Sahoo B]] | |||
[[Category: Seo HD]] | |||
Latest revision as of 07:00, 27 August 2025
Cryo-EM Structure of KSHV ORF74 Apo Dimer at 2.8A
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